Karunesh Remedies

Cetirizine Dihydrochloride

Cetirizine Dihydrochloride

Cetirizine is a second-generation antihistamineused in the treatment of hay fever, allergies, angioedema, and urticaria. It is a major metabolite of hydroxyzine, and aracemicselective receptorantagonist.

 

MOLECULAR STRUCTURE:

  •  Molecular formula : C21H25ClN2O3. 2HCl
  • Molecular weight : 461.8

  • CAS Number : 83881-52-1

  • Application : Anti-histamine, Anti allergic

  • Specification : As per IP/BP/EP/USP

  • Chemical Name [IUPAC Name]: (RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride.

 

Details :

  • Therapeutic Activity :Anti-histamine, Anti allergic
  • Standards :IP / BP / EP
  • CAS. No. :83881-52-1


Specifications

Description

A white or almost white crystalline powder.

Solubility

Freely soluble in water, practically insoluble in acetone, and in methylene chloride.

Appearance of
Solution

5%solution is clear and not more intensely colored than reference solution BY7 .

Identifications

Test A,B,C & D as per IP/BP/EP/USP

PH(1 gm in 20 ml water)

1.2 to 1.8

Loss On Drying

Not more than 0.5% w/w.

Sulphated Ash

Not more than 0.2% w/w.

Related Substance
( By HPLC )

Any Individual Impurity : NMT 0.1%
Impurity A : NMT 0.1%
Impurity B : NMT 0.1%
Impurity C : NMT 0.1%
Impurity D : NMT 0.1%
Impurity E : NMT 0.1%
Impurity F : NMT 0.1%
Total Impurity : NMT 0.3%

Assay
( On Dried Basis )

99% to 100.5% w/w as
C21 H27O3N2Cl3.

Heavy Metals

Not more than 10 ppm