Glimepiride

Glimepiride is an orally available medium-to-long acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation.

Glimepiride is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin production by the pancreas. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce insulin.

MOLECULAR STRUCTURE:

Molecular formula : C₂₄H₃₄N₄O₅S
Molecular weight : 490.6
CAS Number : 93479-97-1
Application :. Anti-Diabetic
Specification : As perUSP/ BP/ EP/ IP
Chemical Name [IUPAC Name]: 1-[[4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]phenyl] sulphony l] -3-trans-(4-methylcyclohexyl)urea.

Specifications

Therapeutic Activity	Anti Diabetic
Standards	USP/ IP / BP/ EP
Cas. No.	93479-97-1

Specifications (As per USP/BP/EP/IP)

Description	A white or almost white crystalline powder.
Solubility	Practically insoluble in water, soluble in dimethylformamide, slightly soluble in methylene chloride, very slightly soluble in methanol.
Identifications by IR	IR Spectrum matches with that of standard
Relative Impurities Impurity B Impurity D Impurity C Unspecified Impurities Sum of Impurities other than B	Not More than 0.4% Not More than 0.2% Not More than 0.1% Not More than 0.1% Not More than 0.5%
Impurity A	Not More than 0.8%
Water (By K.F)	Not more than 0.5% w/w
Heavy Metals	Not more than 10 ppm
Sulphated Ash	Not more than 0.1% w/w.
Assay By HPLC	97% to 102% (anhydrous basis)
Particle Size	100% less than 10 micron